Web75 rows · Human Gene Set: HALLMARK_CHOLESTEROL_HOMEOSTASIS. For the Mouse gene set with the same name, see … WebDec 31, 2024 · Cholesterol Homeostasis and β‐Cell Function. The progressive reduction in β‐cell function and eventual β‐cell loss in patients with T2DM has been attributed to glucotoxicity and elevated free fatty acid levels in association with increased oxidative stress, 75 ER stress, 76 mitochondrial dysfunction, 77 and an elevated inflammatory ...
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WebApr 29, 2024 · Cholesterol-detecting assays were used to explore how the lead compound dysregulates cholesterol homeostasis. To determine the effect of compound treatment on in vivo tumor growth, mice implanted with colorectal cancer cells subcutaneously or within the peritoneum were randomized into two groups and treated with the lead compound or … WebCholesterol has long been implicated in diverse aspects of human health and disease. As this lipid is both vital and lethal, ensuring that its levels are kept in check is important for maintaining health. However, studying cholesterol homeostasis can be challenging due to the extreme hydrophobic nat … country phone code 212
The role of cholesterol in cancer - PMC - PubMed Central (PMC)
WebApr 4, 2016 · Normal cholesterol homeostasis. Cholesterol is an essential lipid for maintaining cellular homeostasis . Besides being a precursor for steroid hormones, and … WebAug 24, 2024 · The oxysterol, 27-hydroxycholesterol, links cholesterol metabolism to bone homeostasis through its actions on the estrogen and liver X receptors. Endocrinology. 152 , 4691–4705 (2011). WebAug 24, 2024 · Dysregulated cholesterol homeostasis results in resistance to ferroptosis increasing tumorigenicity and metastasis in cancer. Nature Communications, 2024; 12 (1) DOI: 10.1038/s41467-021-25354-4; brewers cardinals stream