Cisplatin and sodium thiosulfate

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August undefined, 2024

WebMar 29, 2024 · An important step forward in addressing this was the recent approval of intravenous sodium thiosulfate by the US Food and Drug Administration to treat ototoxicity in pediatric patients with localized, nonmetastatic solid tumors. 11 However, for adult patients, there are no currently approved therapies for cisplatin-induced ototoxicity. Until ... WebSomani et al. 1995), sodium thiosulfate (Markman et al. 1991), S-2-(3-aminopropylamino)-ethyl phosphorothioic acid (WR2721) (Yuhas & Culo 1980), glutathione (GSH, ... cisplatin was given as intraperitoneal infusion (16 ml/kg) over a 30 min. period through syringe pump using butterﬂy needle 23À3/4

Sodium Thiosulfate Administered Six Hours after Cisplatin Does …

WebPEDMARK (sodium thiosulfate injection) is a sterile, preservative-free, clear, colorless solution in a single-dose vial for intravenous use with a pH between 7 and 9. Each vial contains the equivalent of 12.5 grams of sodium thiosulfate pentahydrate (provided as sodium thiosulfate anhydrous 8 grams) in 100 mL solution (125 mg/mL). WebAug 11, 2024 · About Sodium Thiosulfate (STS) Cisplatin and other platinum compounds are essential chemotherapeutic components for many pediatric malignancies. Unfortunately, platinum-based therapies cause ototoxicity in many patients, and are particularly harmful to the survivors of pediatric cancer. rc inheritance\u0027s

Evaluation of prophylactic efficacy of sodium thiosulfate in …

WebMany cisplatin-protective agents have been evaluated: sodium thiosulfate , glutathione (GSH) , GSH ester , vitamin C , and sodium salicylate . However, to date, there are no methods that can completely prevent the loss of hair cells or the dysfunction of auditory nerves in cases of cisplatin-induced ototoxicity. WebCisplatin-induced ototoxicity is caused by irreversible damage to hair cells in the cochlea hypothesized to be due to a combination of reactive oxygen species production and direct alkylation of DNA leading to cell death. Sodium thiosulfate interacts directly with cisplatin to produce an inactive platinum species. Regulatory Status WebSep 20, 2024 · On September 20, 2024, the Food and Drug Administration approved sodium thiosulfate (Pedmark, Fennec Pharmaceuticals Inc.) to reduce the risk of … rcingtec

Sodium Thiosulfate (Intravenous Route) Side Effects - Mayo Clinic

FDA approves sodium thiosulfate to reduce the risk of …

WebJul 6, 2024 · Now, results of the randomized, phase III SIOPEL 6 trial demonstrate that sodium thiosulfate (STS) has considerable efficacy in preventing cisplatin-induced … WebJul 3, 2024 · Cisplatin is widely used for the treatment of a number of solid malignant tumors. However, ototoxicity induced by cisplatin is an obstacle to effective treatment of tumors. The basis for this toxicity has not been fully elucidated. sims 4 terrasse ccWebFeb 14, 2024 · Sodium thiosulfate injection was approved by the FDA in September 2024 to help decrease the risk of hearing loss in patients 1 month or older with localized, non-metastatic solid tumors who will receive treatment with cisplatin. 2 The injection was evaluated in 2 clinical trials: the phase 3 SIOPEL6 trial (NCT00652132) in a pediatric … rc in gre

"WebSodium thiosulfate is a neutralizing agent for cisplatin that protects against renal damage. To determine whether injection of thiosulfate would permit larger doses of cisplatin to … " - Cisplatin and sodium thiosulfate

Cisplatin and sodium thiosulfate

Doseâ Dependent Protection by Lipoic Acid against Cisplatinâ …

WebCisplatin is a bedrock of cancer management and one of the most used chemotherapeutic agents in the treatment of germ cell, lung, bladder, ovarian, and head and neck cancers. Approximately 500,000 patients diagnosed annually with these cancer types in the United States could be candidates for treatment with cisplatin. There is a 5-fold increase in the … WebJun 21, 2024 · The 3-year rate of overall survival was 98% (95% CI, 88 to 100) among children in the cisplatin–sodium thiosulfate group and …

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WebA randomized controlled trial to test the efficacy of trans-tympanic injections of a sodium thiosulfate gel to prevent cisplatin-induced ototoxicity in patients with head and neck cancer. J Otolaryngol Head Neck Surg . 2024;48(1):4. doi: 10.1186/s40463-019-0327-x PubMed Google Scholar Crossref WebSep 9, 2024 · Sodium thiosulfate is a type of medication used to treat cyanide poisoning and to help lessen the side effects from cisplatin. Chemotherapy drugs, such as cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading.

WebApr 9, 2024 · The FDA previously approved sodium thiosulfate injection in September 2024 to decrease the risk of cisplatin-associated hearing loss in pediatric patients. 2 Data from the SIOPEL6 trial and COG ACCL0431 study supported the FDA’s decision to … WebSep 22, 2024 · On September 20, 2024, the U.S. Food and Drug Administration (FDA) approved the use of sodium thiosulfate (Pedmark®) to reduce the risk of ototoxicity associated with cisplatin in pediatric patients aged 1 month and older with localized, nonmetastatic solid tumors.

WebThe chemotherapy agent cisplatin is essential for treatment of many paediatric and adolescent malignancies but in a large proportion of patients results in cisplatin-induced … WebApr 7, 2024 · The active substance of Pedmarqsi is sodium thiosulfate (ATC code not yet assigned), an antidote with a mechanism of action that is not fully understood but is thought to include increasing levels of endogenous antioxidants, inhibition of intracellular oxidative stress and direct interaction with cisplatin to prevent cisplatin-induced damage to …

Webcompared cisplatin with cisplatin plus delayed administration of sodium thiosulfate, aiming to reduce the incidence and severity of cisplatin-related ototoxic effects …

WebThe major toxicities of a cisplatin overdose include nausea and vomiting, renal insufficiency, electrolyte abnormalities, myelosuppression, ototoxicity, peripheral … rcing.com twitterWebNov 30, 2016 · Sodium thiosulfate protects against cisplatin-induced hearing loss in children and is not associated with serious adverse events attributed to its use. Further research is needed to define the appropriate role for sodium thiosulfate among emerging otoprotection strategies. rc in gmatWebFeb 1, 2024 · Sodium thiosulfate is also used to reduce the risk of hearing loss in children 1 month of age and older who are receiving medicines (eg, cisplatin) for cancer that have not spread throughout the body. This medicine is to be given only by or under the immediate supervision of your doctor. This product is available in the following dosage forms: sims 4 tennis racketWebSep 21, 2024 · About PEDMARK® (sodium thiosulfate injection) PEDMARK ® is the first and only U.S. Food and Drug Administration (FDA) approved therapy indicated to reduce … sims 4 terrain gratuitWebAug 2, 2024 · A randomized controlled trial to test the efficacy of trans-tympanic injections of a sodium thiosulfate gel to prevent cisplatin-induced ototoxicity in patients with head … rcing training osrsWebJun 21, 2024 · The addition of sodium thiosulfate, administered 6 hours after cisplatin chemotherapy, resulted in a lower incidence of cisplatin-induced hearing loss among … rci new york cityWebToxicity of cisplatin can be decreased by concomitant administration of sodium thiosulfate, which perhaps chemically inactivates this platinum compound. We studied the disappearance of cisplatin and carboplatin in aqueous solutions of thiosulfate at 37 degrees C by means of liquid chromatography. rcing rs3