Cisplatin mitophagy

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August undefined, 2024

WebThe cardiotoxic effect of chemotherapeutic agents as cisplatin has become a major issue recently. Interference with mitochondrial dynamics, biogenesis, redox status, and apoptosis are the most possible underlying mechanisms. ... Cisplatin has disturbed mitochondrial function and dynamics, dysregulate redox status and induced mitophagy and ... WebJan 16, 2024 · We examined the sensitivity of 20 human cancer cell lines to X-rays, carbon ions, or cisplatin in a clonogenic survival assay (Figs 1,2).Details of the parameters …

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WebJan 13, 2024 · Abstract. Cisplatin is an efficacious anticancer agent, but its use is limited by ototoxicity and resultant irreversible sensorineural hearing loss. … WebSep 25, 2024 · Meanwhile, mitophagy indicated by autophagosome formation and LC3B-II accumulation was also attenuated in PINK1 knockout rats. Renal expression of PINK1 and Parkin were down-regulated while BNIP3L was up-regulated by cisplatin treatment, indicating a major role of BNIP3/BNIP3L pathway in cisplatin-induced mitophagy. graphite spray mitre 10

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WebDec 31, 2024 · Since metformin is used as adjuvant drug to increase the efficacy of cisplatin-based neoadjuvant chemotherapy, we co-treated tumour cells with micromolar doses of metformin in the presence of cisplatin observing a marked reduction of MAP1LC3B-II and an increase of caspase 3 cleavage. ... Mitophagy, as assessed by … WebNov 1, 2024 · Cisplatin is a widely used chemotherapeutic drug with notorious toxicity in the kidneys, which involves mitochondrial dysfunction and damage in renal tubular cells. Mitophagy is a form of selective autophagy that removes damaged or dysfunctional mitochondria to maintain cellular homeostasis. WebBackground: To study the protective effect of berberine (BBR) on cisplatin-induced acute kidney injury (AKI) and its effect on mitophagy. Methods: (I) Male C57BL/6 mice aged 6-8 weeks were randomly divided into control group (saline), cisplatin group (cisplatin), and cisplatin + BBR (5, 10 mg/kg) groups. chisholm chisholm

Mitophagy in carcinogenesis, drug resistance and …

Mitophagy alleviates cisplatin-induced renal tubular …

WebCisplatin exerts its therapeutic efficacy by interfering with DNA replication but also by interacting with other nucleophilic species within cells, including side chains of mitochondrial proteins and nucleotides. Mitochondria are key signaling hubs that fundamentally contribute to cancer development and progression. WebJun 1, 2024 · Modulation of cisplatin-induced apoptosis by stimulation or suppression of mitophagy. (A) Cisplatin stimulates apoptosis in HCT116 and SK-N-BE(2) assessed by … chisholm chisholm and kilpatrick ltdWebJul 5, 2024 · Mitophagy is a cytoprotective process in the adaptation to chemotherapy drug treatment. Therefore, targeting mitochondria is regarded as a promising anticancer … chisholm chisholm kilpatrick glassdoor

"WebCisplatin has disturbed mitochondrial function and dynamics, dysregulate redox status and induced mitophagy and apoptosis, in the other hand semaglutide treatment has … " - Cisplatin mitophagy

Cisplatin mitophagy

Chaetomugilin J Enhances Apoptosis in Human Ovarian Cancer

WebNov 11, 2024 · Mitophagy reportedly can prevent diabetic nephropathy, cisplatin-induced AKI and other related nephropathy. In this study, we evaluated the correlation between mitophagy and the protective effect of the Nrf2 activator farrerol on cisplatin-induced CKD by using C57BL/6 wild-type and Nrf2 knockout mice. WebSep 18, 2024 · NCBI Bookshelf

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WebCisplatin is widely recommended in combination for the treatment of tumors, thus inevitably increasing the incidence of cisplatin-induced acute kidney injury. Mitophagy is a type of mitochondrial quality control mechanism that degrades damaged mitochondria and maintains cellular homeostasis. WebMar 15, 2024 · It has been found that PNS is able to alleviate cisplatin-induced nephrotoxicity by inducing BNIP3-mediated mitophagy via hypoxia-inducible factor-1α (HIF-1α). PNS treatment restores renal function via attenuating the accumulation of injury mitochondria and cell apoptosis in TECs ( Liang et al., 2024 ; Li et al., 2024c ).

WebThe synergistic effect of cisplatin and the DRP1 inhibitor on HCC was assessed in vitro and in vivo. Accordingly, cisplatin induced mitophagy in surviving HCC cells by activating DRP1. The DRP1 inhibitor (Mdivi‑1) increased the apoptosis of cisplatin‑treated HCC cells by targeting mitophagy. In vivo, we initially identified the occurrence of autophagy/mitophagy during cisplatin treatment in C57/BL6 mice. C57BL/6 mice (male, 8–10 weeks old) were intraperitoneally injected with 30 mg/kg cisplatin or saline as control. Blood samples were harvested to measure serum creatinine and blood urea … See more To assess the role of mitophagy on cisplatin-induced AKI in C57BL/6 mice, we investigated the effect of rapamycin, a pharmacological … See more Under unchallenged conditions, serum creatinine, and BUN were at low levels in both Parkin-KO mice and their WT littermates, indicating that renal function was normal in these … See more To determine the role of PINK1/Parkin pathway of mitophagy in cisplatin-induced nephrotoxicity, we tested Parkin- or PINK1-KO mouse models. We first verified Parkin deficiency in … See more

WebMar 28, 2024 · Cisplatin chemotherapy often causes acute kidney injury (AKI) in cancer patients. There is increasing evidence that mitochondrial dysfunction plays an … WebOct 7, 2024 · Chaetomugilin J Enhances Apoptosis in Human Ovarian Cancer A2780 Cells Induced by Cisplatin Through Inhibiting Pink1/Parkin Mediated Mitophagy Onco Targets Ther. 2024 Oct 7;13:9967-9976. doi: 10.2147/OTT.S273435. eCollection …

WebMar 28, 2024 · Although mitophagy is considered of particular importance in protecting against AKI, little is known of the precise role of mitophagy and its molecular mechanisms during cisplatin-induced nephrotoxicity. Also, evidence that activation of mitophagy improved mitochondrial function is lacking.

WebThe role of autophagy/mitophagy was investigated by transient transfection of siATG14, GFP-LC3, tF-LC3, mKeima-Red-Mito7 and Western blot analysis of autophagic and mitochondrial proteins. Results: In vitro and OSCC tissue double labelling confirmed that CD44+cells co-expresses ABCB1 and ADAM17. chisholm chisholm kilpatrick addressWebNov 1, 2024 · Abstract. Cisplatin is a widely used chemotherapeutic drug with notorious toxicity in the kidneys, which involves mitochondrial dysfunction and damage in renal … graphites system satWebCisplatin is widely recommended in combination for the treatment of tumors, thus inevitably increasing the incidence of cisplatin-induced acute kidney injury. Mitophagy is a type of … graphite spray for sliding doorsWebApr 22, 2024 · Specifically, levels of the mitophagy receptor BNIP3 are higher both in resistant cells and in ovarian cancer patient samples resistant to platinum-based treatments. Genetic BNIP3 silencing or pharmacological inhibition of autophagosome formation re-sensitizes these cells to CDDP. graphite spray usesWebNov 11, 2024 · Mitophagy reportedly can prevent diabetic nephropathy, cisplatin-induced AKI and other related nephropathy. In this study, we evaluated the correlation between … chisholm chisholm kilpatrick email addressWebThe results revealed that cisplatin‑resistant A549 cells contained high levels of APE1, and exhibited elevated levels of autophagy. The levels of m‑APE1 and t‑APE1 protein were increased in the A549/DDP cells when compared with these levels in the A549 cells. graphite staffingWebApr 22, 2024 · Cisplatin (CDDP) is commonly used to treat a multitude of tumors including sarcomas, ovarian and cervical cancers. graphite stage