WebCTSB protein expression summary. This gene encodes a member of the C1 family of peptidases. Alternative splicing of this gene results in multiple transcr ipt variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate multiple protein products. WebJan 3, 2011 · CTSB may initiate proteolytic pathways crucial for IBC invasion. Thus, our data demonstrate that CTSB may be a potential prognostic marker for lymph node metastasis in IBC. Background Inflammatory breast cancer (IBC) is the most lethal form of primary breast cancer, with a 3-year survival rate of 40% as compared to 85% for non …
Did you know?
WebFinally, CTSB expression was evaluated in 69 resected tumor specimens, and high expression was associated with the patients' clinicopathological features and surgical outcomes. The present results suggested that CTSB is a biomarker for poor survival in patients with pancreatic cancer, which is possibly associated with P-CSLCs. WebOct 11, 2024 · Previously we identified CST6 as a secretory protein significantly downregulated in bone-metastatic breast cancer cells. Functional analysis showed that …
WebOct 10, 2024 · Cathepsin B, elevated in several types of solid tumors, degrades proteins in the extracellular matrix and basement membrane and indirectly activates proteinases, like urokinase plasminogen activator, to facilitate cancer progression and dissemination. WebJun 1, 2024 · CTSB overexpression has been reported for numerous malignancies including brain, lung, prostate, breast, and colorectal cancers ( Krepela, Vicar, & Cernoch, 1989; Krepela, Kasafirek, Novak, & Viklicky, 1990; Rempel et …
WebJun 4, 2024 · A metastatic hormone receptor–positive breast cancer, usually resistant to immunotherapy, is successfully treated with tumor-infiltrating lymphocytes enriched for neoantigen reactivity ... WebApr 8, 2024 · Magnetic resonance imaging (MRI) is a superior and noninvasive imaging technique with unlimited tissue penetration depth and superb spatiotemporal resolution, however, using intracellular self-assembly of Gd-containing nanoparticles to enhance the T 2-weighted MR contrast of cancer cells in vivo for precise tumor MRI is rarely reported. …
Web1 day ago · Galectin-3 is a galactoside-binding protein that is commonly overexpressed in many epithelial cancers. It is increasingly recognized as a multi-functional, multi-mode promoter in cancer ...
WebThe CTSB gene is located at chromosome 8p22, consisting of 13 exons. The promoter of CTSB gene contains a GC-rich region including many SP1 sites, ... Cathepsin B is … sims 4 comic shopWebDec 28, 2024 · CTSB in serum EVs promoted angiogenesis with significant relevance to tumour clinicopathology. To further investigate whether various CTSB levels in serum … rblx earnings historyWebDec 5, 2024 · Although CTSB has been extensively studied in a wide variety of human cancers, the molecular basis regulating its dual functions as either a pro-oncogenic or pro-apoptotic enzyme is poorly understood. Furthermore, regulators that control the dual functions of CTSB in cancer progression remain to be identified. sims 4 command barWebApr 13, 2024 · CTSB is a desirable biomarker in the detection of numerous malignancies including glioblastoma, oral, laryngeal, gastric, esophageal, pancreatic, colorectal, and prostate, since the overexpression of CTSB is linked to cancer invasion and progression [5,6,7,8]. Therefore, determining CTSB levels in biological systems with accuracy and ... sims 4 coming out on consoleWebMar 11, 2024 · CTSB could specifically and sensitively indicate mesenchymal glioma. Upregulated CTSB was an independent hazard correlated with poor survival. CTSB … rblx earnings per shareWebDec 17, 2024 · Among eleven members of the cysteine cathepsin family in lysosome, CTSB plays a unique role in the regulation of autophagy, cellular stress signaling, and cell death in cancer [13]. We first analyzed the expression and activity of CTSB in PANC1 and MIAPaCa2 cells, which are human pancreatic cancer cell lines sensitive to ferroptosis … sims 4 command center modssims 4 command center mod deutsch