Cynk-001 clinical trial

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August undefined, 2024

WebJan 22, 2024 · The clinical investigation of CYNK-001 in patients with GBM is expected to be the first clinical trial in the U.S. to investigate intratumoral administration of an allogeneic NK cell therapy ... WebSep 8, 2024 · The trial will evaluate the safety and clinical efficacy of CYNK-001 in SARS-CoV-2 positive subjects as measured by clearance of the SARS-CoV-2 and improvement in clinical symptoms or improvement ...

NK Cell Platform – Celularity

WebJul 6, 2024 · The companies in January launched a clinical and manufacturing collaboration designed to expand the therapeutic use of Celularity’s CYNK-001 to COVID-19. Sorrento and Celularity agreed to... WebPhase I will utilize a 3+3 open label design, and will enroll up to two dosing cohorts of CYNK-001 given on Day 2 or Days 2, 7, 14 post ASCT. Phase II will utilize the phase I determined dose, and will be double blinded/ randomized to CYNK-001 or placebo. Number of Arms: 2: Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes ... biographic educational publications

A phase I multi-dose study of human placental …

WebNov 4, 2024 · CYNK-001 is a cryopreserved, allogeneic, off-the-shelf, NK cell therapy developed from placental hematopoietic stem cells grown in a laboratory as a potential … WebJan 22, 2024 · The FDA cleared an investigational new drug application for CYNK-001, a natural killer cell therapy, for the treatment of glioblastoma multiforme. CYNK-001 (Celularity) is an investigational,... WebFeb 1, 2024 · Experimental: Phase IIa Surgical rGBM CYNK-001 at MPD IV and IC. To evaluate efficacy and safety of CYNK-001 administrations in recurrent GBM at maximum … biographic data nursing

Natural Killer Cell (CYNK-001) Infusions in Adults With COVID …

Celularity Announces FDA Clearance of Landmark IND for CYNK-001…

WebAug 11, 2024 · CYNK-001 has the potential to inhibit viral infection by killing host cells through indirect immune responses. CYNK-001 expresses NKG2D and DNAM-1 receptors in addition to cytotoxicity receptors NKp30, NKp44, and NKp46. ... Clinical Trials Clinical Trials . Phase Status Purpose Conditions Count; 1: WebApr 3, 2024 · CYNK-001 is the only cryopreserved allogeneic, off-the-shelf NK cell therapy being developed from placental hematopoietic stem cells. The company suggests that … biographic data of patientWebNov 15, 2024 · Another of Celularity's candidates, CYNK-001, is being assessed in a phase 1 clinical trial (NCT04310592) that expanded its enrollment from patients with minimal residual disease (MRD) to also include patients with relapsed/refractory acute myeloid leukemia (AML). 3. daily bread food bank toronto volunteer

"WebSep 10, 2024 · The trials will gauge the effectiveness of the treatment as well as any adverse patient reactions to the NK-cells. By mid-May, CYNK-001 was already being used in Food & Drug Administration ... " - Cynk-001 clinical trial

Cynk-001 clinical trial

UCI opens first natural killer cell clinical trial for recurrent ...

WebMar 18, 2024 · CYNK-001 is a non-genetically modified cryopreserved allogeneic placental hematopoietic stem cell-derived NK cell therapy that is being investigated as an off-the …

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WebCYNK-001 is the only cryopreserved allogeneic, off-the-shelf NK cell therapy developed from placental hematopoietic stem cells. CYNK-001 is being investigated as a potential treatment option in adults with COVID-19, as well as for … WebJun 2, 2024 · Background: CYNK-001 is a CD56+CD3- enriched, off-the-shelf, allogeneic natural killer (NK) cell product expanded from placental CD34 cells. CYNK-001 exhibits …

WebDec 29, 2024 · CYNK-001 contains NK cells derived from human placental CD34+ cells and culture-expanded. In a new phase 1 multi-dose study (NCT04310592) of approximately 56 adult patients with AML, CYNK-001 cells will be given after lymphodepleting chemotherapy to determine its safety and whether NK cells be used to treat AML. 1,2 WebApr 28, 2024 · Brief Summary: This study is a Phase 1 / 2 trial to determine the safety and efficacy of CYNK-001, an immunotherapy containing Natural Killer (NK) cells derived …

WebJul 1, 2024 · Background CYNK-001 is a cryopreserved, allogeneic, off-the-shelf natural killer (NK) cell investigational product derived from placental CD34+ cells. CYNK-001 … WebThis study will find the maximum tolerated dose or the maximum planned dose of CYNK-001 which contains natural killer (NK) cells derived from human placental CD34+ cells and culture-expanded. CYNK-001 cells will be given after lymphodepleting chemotherapy. The safety of this treatment will be evaluated, and researchers want to learn if NK cells ...

WebJan 4, 2024 · CYNK-001 is the only cryopreserved allogeneic, off-the-shelf NK cell therapy that incorporates CD56-positive and CD3-negative NK cells expanded from human placental CD34-positive cells and is being …

WebThe purpose of this clinical research study is to evaluate the safety (any good or bad effects) of CYNK-001 and to assess the effects of CYNK-001 on your Acute Myeloid Leukemia … biographic information for deferred actionWebestimated completion June 2024 Description Summary This study is a Phase 1 / 2 trial to determine the safety and efficacy of CYNK-001, an immunotherapy containing Natural Killer (NK) cells derived from human placental CD34+ cells and culture-expanded, in patients with moderate COVID-19 disease. Official Title biographic differencesWebCYNK-001 is the only cryopreserved allogeneic, off-the-shelf NK cell therapy developed from placental hematopoietic stem cells. CYNK-001 is being investigated as a potential … biographic formWebAug 5, 2024 · The first co-primary endpoint is to determine the virologic efficacy of CYNK-001 in facilitating the clearance of SARS-CoV-2 from mucosal specimens and/or peripheral blood. The second co-primary endpoint is to assess the impact of treatment with CYNK-001 on clinical symptoms among patients with COVID-19 related lower respiratory tract … biographic information meaningWebApr 2, 2024 · “We congratulate Celularity’s rapid progress in moving CYNK-001 from immune-oncology applications to a COVID-19 clinical trial since our first announcement of the collaboration on January 29, 2024. We will do whatever we can to assist Celularity in its fight against COVID-19 pandemic.” About Sorrento Therapeutics, Inc. biographic filmsWebCYNK-001 cells will be given after lymphodepleting chemotherapy. The safety of this treatment will be evaluated, and researchers want to learn if NK cells will help in treating … biographic dollWebSep 8, 2024 · CYNK-001 is being investigated as a potential treatment option in adults with COVID-19, as well as for various hematologic cancers and solid tumors. biographic information def