Web11 Apr 2024 · Although augurin has been shown to be implicated in a variety of processes, ranging from tumorigenesis, inflammation and infection to neural stem cell proliferation, hypothalamo-pituitary adrenal axis regulation and osteoblast differentiation, the molecular mechanisms of its biological effects and the signaling pathways it regulates are still … WebSGLT2is have pleiotropic pharmacological effects that include those related to their glucose-lowering effects and those that are independent of glucose lowering effects. Some pharmacological mechanisms, such as the effects on sodium-glucose cotransporter-2 (SGLT2), are well understood and linked to evidence in clinical outcome studies.

Effects of lovastatin on breast cancer cells: a proteo …

Web17 Feb 2024 · A pleiotropic effect, thus, refers to the specific effect of a single gene on multiple areas, with mixed symptoms, or organ functions. For an instance, a gene that … Web9 Mar 2024 · Among mechanisms that might mediate this relationship, we found evidence that blood lymphocyte count might influence albuminuria. This study may also support a … grey marble mosaic tile

Interaction between mutation type and gene pleiotropy drives …

Web14 Nov 2024 · Moreover, we present a comprehensive overview of the pleiotropic genetic architecture of this trait and indicate 19 gene sets associated with CRP as potential … Web13 May 2024 · To address the potential pleiotropic effects of genetic variants, four MR analytical methods were performed to evaluate the causal effects of LSB and PA on … Web8 Apr 2024 · SNPs with any potential pleiotropic effects were further excluded in sensitivity analyses. Further, multiple pleiotropy-robust MR approaches that can relax the ‘independence’ and ‘exclusion-restriction’ assumptions were applied as additional sensitivity analyses (Additional file 1 : Supplementary Methods). grey marble thank you gift bag