WebMotivated by reports that Siah-1 serves as a simple E3 ligase and the observation that only Siah-1 is required for the ubiquitination of -catenin (Fig. 1B, lane 9), a series of in vitro … WebNov 22, 2011 · The SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex mediates polyubiquitination of proteins targeted for degradation, thereby controlling a plethora of …

Sooyoung Lee - Scientist II - Vir Biotechnology, Inc. LinkedIn

WebSCF-Skp2 E3 ligase is a target for cancer therapy, but there have been no reports about Skp2 as a target for IPF. Here we demonstrate that Skp2 is a promising therapeutic target for … WebDec 10, 2015 · Within the E3 ligase family, cullin-RING ligases (CRLs) comprise the largest class, and in this group the SCF ubiquitin ligases are one of the best-understood complexes [2,6]. They are composed of yeast Cdc53 (mammalian cullin-1), Skp1, Rbx1, and one of the multiple F-box proteins, which bind substrates and confer specificity to the complex [ 7 , 8 ]. kanbanflow free download

The SCF E3 Ligase AtPP2-B11 Plays a Negative Role in Response …

WebNov 9, 2015 · Many ubiquitin ligases belong to the Skp1, Cullin, and F-box (SCF) family, characterized by the presence of S-phase kinase-associated protein 1 (Skp1), Cullin-1 (Cul1), and an F-box protein, with the latter serving as the substrate recognition subunit (3, 4).F-box proteins contain the collinear motif for which they are named and, frequently, a dedicated … WebApr 3, 2007 · The ubiquitin ligase complex SCF Fbs1, which contributes to the ubiquitination of glycoproteins, is involved in the endoplasmic reticulum-associated degradation … WebJan 3, 2024 · The SCF β-TRCP E3 ubiquitin ligase complex plays pivotal roles in normal cellular physiology and in pathophysiological conditions. Identification of β-transducin repeat–containing protein (β-TRCP) substrates is therefore critical to understand SCF β-TRCP biology and function. We used a β-TRCP–phosphodegron motif–specific antibody … kanban for infrastructure projects