Signaling functions of phosphatidic acid
WebThe simple structure of phosphatidic acid (PA) belies its complex biological functions as both a key phospholipid biosynthetic intermediate and a potent signaling molecule. In the … WebDec 2, 2011 · The lipid phosphatidic acid (PA) has important roles in cell signaling and metabolic regulation in all organisms. New evidence indicates that PA also has an …
Signaling functions of phosphatidic acid
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WebMar 17, 2024 · Phosphatidic acid (PA) is a minor membrane glycerolipid composed of glycerol-3-phosphate and two fatty acid chains. PA is an intermediate and regulator of … Web(2011) Phosphatidic Acid Phosphatases in Seed Plants ~ Involvement in Membrane Lipid Biosynthesis and Signal Transduction. Seikagaku (Biochemistry) 82:1137-40 [Review in Japanese] Yuki Nakamura, Koichi Kobayashi, Mie Shimojima and Hiroyuki Ohta*. (2010) Biosynthesis and Function of Monogalactosyldiacylglycerol, the Signature Lipid of …
WebJul 2, 2010 · Phospholipase D2 (PLD2) generates phosphatidic acid through hydrolysis of phosphatidylcholine. PLD2 has been shown to play a role in enhancing tumorigenesis. The epidermal growth factor receptor (EGFR) can both activate and interact with PLD2. Murine lymphoma EL4 cells lacking endogenous PLD2 present a unique model to elucidate the … WebMore importantly, our RNA-seq analysis and jasmonic acid (JA) treatment demonstrated that OsRbohI regulates rice growth through JA synthesis and signaling pathways. Compared with the control, the results showed that the KO mutants were more sensitive to JA, whereas the OE lines were less sensitive to JA. Collectively, our results reveal a novel ...
WebAug 22, 2024 · A Phosphatidic Acid (PA) conveyor system of continuous intracellular transport from cell membrane to nucleus maintains EGF receptor homeostasis Oncotarget May 2016 DOI: 10.18632/oncotarget.9685 WebFigure 1. Purification and biochemical characterization of FLAG-lipin 3. A, HeLa cells were infected with adenovirus expressing FLAG-lipin 3. After 2 days, cells were homogenized in buffer A, and the lipin 3 protein was affinity-purified, eluted with FLAG peptide, and dialyzed. An aliquot of the purified FLAG-tagged lipin 3 was resolved by SDS-PAGE, and the gel was …
WebHowever, the mediators of these signaling pathways are unknown. Using U937 leukemic cells, we evaluated the effect of docetaxel on phosphatidylcholine (PC) and its metabolites, phosphatidic acid (PA) and diacylglycerol (DAG), and their impact on MAPK and NF-kappa B activation, as well as on Raf-1 and Bcl-2 phosphorylation.
WebIn the yeast Saccharomyces cerevisiae, Dgk1 diacylglycerol (DAG) kinase catalyzes the CTP-dependent phosphorylation of DAG to form phosphatidic acid (PA). The enzyme in … graeme simpson msp twitterWebPhosphatidic acid biogenesis and signaling pathways. PA is a bioactive lipid that sits at the nexus of a number of lipid synthetic and signaling pathways (Fig. 1) (Jenkins and … graeme shirley strachanWeb2 days ago · Lysophosphatidic acid (LPA) is a bioactive lipid mediator that regulates a variety of cellular functions such as cell proliferation, migration, surviv… graeme shirtleyWebApr 11, 2024 · Signal transducer and activator of transcription 6 (STAT6) is a multifunctional protein that plays critical functions in cell proliferation, apoptosis, differentiation, and angiogenesis. Mutations in STAT6 may contribute to the development of certain complex diseases such as cancer. This study examined single amino acid substitutions in STAT6 … graeme smith alice springsWebJun 4, 2024 · Phosphatidic acid (PA) is a simple glycerophospholipid with a well-established role as an intermediate in phospholipid biosynthesis. In addition to its role in lipid … graeme simsion biographyWebMar 15, 2006 · Phosphatidic acid (PA) has emerged as a new class of lipid mediators involved in diverse cellular functions in plants, animals, and microorganisms. … graeme simsion ted talkWebOct 13, 2006 · Arabidopsis PDK1 activity is regulated by binding to the lipid phosphatidic acid (PA) resulting in activation of the oxidative stress-response protein kinase OXI1/AGC2-1. Thus there is an inferred link between lipid signaling and oxidative stress signaling modules. Among a panel of hormones and stresses tested, we found that, in addition to … graeme skelton thomson resources